Stem Cell Transplantation

High Stem Cell Doses May Be Detrimental

Published in Blood Weekly, December 6th, 2001

by Michael Greer, senior medical writer - Hematopoietic stem cell grafts with high levels of CD34⁺ cells may reduce the chance of survival after allogeneic peripheral blood progenitor cell (allo-PBT) transplantation, researchers in Spain warn.

"Although the association of the number of donor T cells with the clinical outcome has been studied extensively, the optimum number of progenitor cells that should be administered to patients is unknown," explained Alvaro Urbano-Ispizua and colleagues at the University of Barcelona's August Pi i Sunyer Institute for Biomedical Research.

While the dangers of insufficient stem cell grafts are well...

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Source: Blood Weekly (2001-12-06)

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