Allergic Asthma

Leukotriene Levels Raised In Aspirin-Induced Asthma

Published in Blood Weekly, December 20th, 2001

by Michael Greer, senior medical writer - Aspirin raises levels of some allergic mediators in patients suffering from asthma triggered by the drug, according to researchers in Turkey.

"The decrease in prostaglandin E₂ (PGE₂ ) release due to aspirin (ASA)-induced cyclooxygenase inhibition and the increment in cysteinyl leukotriene (Cys-LT) release secondary to the removal of the inhibitory effect of PGE₂ on Cys-LT release have been suggested in the pathogenesis of aspirin-induced asthma (AIA)," explained Gulfem Celik and colleagues at the Ankara University School of Medicine.

Aspirin exposure elevated Cys-LT levels...

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Source: Blood Weekly (2001-12-20)

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