Leukemia Therapy

Arsenic Trioxide Works Through Caspase Pathway

Published in Blood Weekly, February 7th, 2002

by Michael Greer, senior medical writer - The antineoplastic agent arsenic trioxide uses the caspase pathway to induce apoptosis in leukemic cells, researchers in the United States and France report.

"Treatment of patients with adult T cell leukemia-lymphoma (ATLL) using conventional chemotherapy has limited benefit because human T-cell leukemia virus type 1 (HTLV-1) cells are resistant to most apoptosis-inducing agents," with the recently discovered exception of arsenic trioxide, explained Renaud Mahieux and colleagues at the Pasteur Institute in Paris and the U.S. National Cancer Institute in Bethesda, Maryland.

Mahieux and coauthors determined...

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Source: Blood Weekly (2002-02-07)

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