Thrombosis

Anticoagulant Drugs Can Lower Endothelial Protein C Receptor Levels

Published in Blood Weekly, February 7th, 2002

by Michael Greer, senior medical writer - Some anticoagulant drugs reduce levels of a protein C receptor in humans, researchers in the United States and Europe say.

"The endothelial protein C receptor (EPCR) facilitates protein C activation and plays a protective role in the response to Escherichia coli-mediated sepsis in primates," according to Dr. Deborah J. Stearns-Kurosawa and colleagues at the Oklahoma Medical Research Foundation in Oklahoma City, Scientific Institute HS Raffaele in Milan, Italy, and Diagnostica Stago, Inc., in Gennevilliers, France.

Drugs that inhibit thrombin production also reduce the generation of a soluble form of...

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Source: Blood Weekly (2002-02-07)

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