Blood Products

Leukodepletion Prevents False Erythrocyte Senescence Signaling

Published in Blood Weekly, February 28th, 2002

by Michael Greer, senior medical writer - Removing leukocytes from stored red blood cell products helps prevent erythrocyte degradation, according to researchers in the United States and Europe.

"In vivo phagocytosis of senescent red blood cells (RBCs) by macrophages occurs 120 days after their release into the circulation," explained Dr. Daniela Bratosin at the National Institute of Biological Science Research and Development in Bucharest, Romania, and colleagues in France and the U.S. participating in a multicenter study.

The molecular signaling that triggers this process is replicated by leukocyte enzymes in stored blood products, Bratosin and...

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Source: Blood Weekly (2002-02-28)

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