Drug Delivery

Band 3 Cross-Linking Improves Drug Delivery Via Red Blood Cells

Published in Blood Weekly, February 28th, 2002

by Michael Greer, senior medical writer - Disrupting the band 3 anion transporter protein on red blood cells improves these cells' ability to deliver therapeutic agents, researchers in Spain report.

"Chemical alteration of red blood cells (RBCs) can induce increased phagocytosis of modified cells by macrophages," explained Jose A. Jordan and colleagues at the University of Alcala in Madrid.

Reagents that induce band 3 cross-linking increase the likelihood that RBCs will be consumed by macrophages, the targets of many drugs, Jordan and coauthors said.

The researchers evaluated several different methods for altering RBC membranes to...

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Source: Blood Weekly (2002-02-28)

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