AIDS and HIV Therapy

Monocytes can act as viral reservoir in HAART patients

Published in Blood Weekly, March 7th, 2002

by Michael Greer, senior medical writer - HIV can infect monocytes in patients treated with highly active antiretroviral therapy (HAART), researchers in the United States report.

"In vitro studies show that human immunodeficiency virus type 1 (HIV-1) does not replicate in freshly isolated monocytes unless monocytes differentiate to monocyte-derived macrophages," according to Dr. Tuofu Zhu and colleagues at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle.

However, this was not the case in vivo, as Zhu and coauthors found.

The researchers tracked HIV replication and evolution in seven patients...

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Source: Blood Weekly (2002-03-07)

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