Stem Cell Transplantation

STAT5 enables long-term lymphomyeloid recovery

Published in Blood Weekly, March 28th, 2002

by Michael Greer, senior medical writer - The transcription factor STAT5 regulates the ability of transplanted stem cells to effect hematopoietic recovery in their new host, researchers say.

"Signal transducers and activators of transcription (STATs) are intracellular mediators of cytokine receptor signals," explained Kevin D. Bunting and colleagues at the American Red Cross Holland Laboratory in Rockville, Maryland, St. Jude Children's Research Hospital in Memphis, Tennessee, the Howard Hughes Medical Institute in Chevy Chase, Maryland, and the Research Institute of Molecular Pathology, Vienna, Austria. "Because many early acting growth factors have been implicated in...

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Source: Blood Weekly (2002-03-28)

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