Septicemia
Antithrombin reduces inflammatory cytokine output
Published in Blood Weekly, April 18th, 2002
"Antithrombin (AT) prevents Escherichia coli-induced hypotension in animal models of sepsis, and it further reduces the mortality of patients with septic shock," explained Hirotaki Isobe and colleagues at the Kumamoto University School of Medicine in Kumamoto.
The anticoagulatory protein appears to reduce the production of some proinflammatory cytokines in rats, preventing a dangerous chain reaction, Isobe and coauthors found.
AT-treated animals exposed to...
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Source: Blood Weekly (2002-04-18)
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