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Cardiology

Coronary blood flow reduced by plaque-associated tissue factor

Published in Blood Weekly, May 2nd, 2002

by Michael Greer, senior medical writer - A protein found in atherosclerotic plaque can severely impair coronary blood flow, researchers warn.

"Defined angiographically, no-reflow (NR) manifests as an acute reduction in coronary flow in the absence of epicardial vessel obstruction," explained Dr. Diana Bonderman and colleagues at the Mount Sinai School of Medicine in New York City, the University of Vienna, and the Ludwig Boltzmann Institute for Cardiovascular Research and the Institute for Molecular Oncology in Vienna, Austria. "One candidate protein to cause coronary NR is tissue factor (TF), which is abundant in atherosclerotic plaque and a cofactor for activated...

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