Transplant Medicine

Prograf plus rapamycin: Combined use safe and effective

Published in Blood Weekly, June 6th, 2002

Prograf (tacrolimus) can be used safely in combination with the new, adjunctive immunosuppressant, rapamycin, according to results announced at the American Transplant Congress meeting .

Antirejection therapy is usually based on the addition of one or more adjunctive agents, such as steroids, mycophenolate mofetil, or rapamycin, to a cornerstone immunosuppressant such as Prograf or ciclosporin.

When rapamycin was first launched, however, there were concerns that it might not be appropriate to use it in combination with Prograf due to hypothetical similarities in the mode of action of the two agents. These concerns have since been dispelled, and...

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Source: Blood Weekly (2002-06-06)

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