Leukemia

Tax protein-induced drug resistance mediated by surprising agent

Published in Blood Weekly, June 6th, 2002

by Michael Greer, senior medical writer - Researchers in Japan have shed new light on the mechanisms of drug resistance conferred by the leukemic Tax protein.

Dr. Yoshimune Sakaki and colleagues working at Kagoshima University in Kagoshima performed a study to investigate the "significance of human T-cell lymphotropic virus type I (HTLV-I) Tax protein-induced resistance to anticancer drugs and the relationship between Tax and multidrug resistance proteins."

The effects of Tax were mediated by other proteins linked to drug resistance, but not the proteins widely assumed to be upregulated by Tax, Sakaki and coauthors found.

They...

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Source: Blood Weekly (2002-06-06)

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