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AIDS and HIV Therapy

Interleukin-7 increases risk of naive T-cell infection

Published in Blood Weekly, July 25th, 2002

by Michael Greer, senior medical writer - The immunomodulatory cytokine interleukin (IL)-7 potentiates HIV infection of some cells thought to be safe from the virus, researchers in the United States report.

"Although human immunodeficiency virus (HIV) gag/pol DNA can be detected in naive T cells, whether naive T cells can be productively infected by HIV is still questionable," explained Carolyn M. Steffens and colleagues at Rush University's Rush-Presbyterian-St. Luke's Medical Center in Chicago.

Productive infection of naive T cells is indeed possible, but only in the presence of IL-7, Steffens and coauthors found.

The...

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