HIV/AIDS Pathogenesis

Dendritic cell subtype affects viral transmission ability

Published in Blood Weekly, August 8th, 2002

by Michael Greer, senior medical writer - Researchers in the Netherlands have shed new light on the transmission of HIV infection by antigen-presenting cells.

"Dendritic cells (DC) support human immunodeficiency virus type 1 (HIV-1) transmission by capture of the virus particle in the mucosa and subsequent transport to the draining lymph node, where HIV-1 is presented to CD4+ Th cells," explained Rogier W. Sanders and colleagues working at the University of Amsterdam. "The mechanism of viral transmission from DC to T cells is currently unknown."

An adhesion molecule expressed by Th1 DCs appears to play a key role in the process of T cell infection,...

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Source: Blood Weekly (2002-08-08)

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