Published in Blood Weekly, August 8th, 2002
"Dendritic cells (DC) support human immunodeficiency virus type 1 (HIV-1) transmission by capture of the virus particle in the mucosa and subsequent transport to the draining lymph node, where HIV-1 is presented to CD4+ Th cells," explained Rogier W. Sanders and colleagues working at the University of Amsterdam. "The mechanism of viral transmission from DC to T cells is currently unknown."
An adhesion molecule expressed by Th1 DCs appears to play a key role in the process of T cell infection,...
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