Stem Cell Transplantation

Novel selective T-cell depletion method may reduce graft-versus-host disease risk

Published in Blood Weekly, August 8th, 2002

by Michael Greer, senior medical writer - Researchers in Canada have developed a novel technique for selectively destroying activated T-cells, which they say could help prevent graft-versus-host disease after stem cell transplantation.

"T lymphocytes have been found to harbor P-glycoprotein (Pgp) and to demonstrate modulation of its ion channel transporter function according to the state of activation of T lymphocytes," explained Martin Guimond and colleagues working at the Maisonneuve-Rosemont Hospital Research Center, the University of Montreal, and Theratechnologies Inc., all in Montreal.

Since Pgp is active only on resting T cells, a cytotoxic...

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Source: Blood Weekly (2002-08-08)

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