Stem Cell Transplantation

Nonmyeloablative conditioning may raise cytomegalovirus infection risk

Published in Blood Weekly, August 15th, 2002

by Michael Greer, senior medical writer - Stem cell transplant conditioning regimens that spare the recipients' bone marrow may also increase their risk of post-transplant cytomegalovirus (CMV) infection, researchers warn.

"Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of infections and immune reconstitution," explained Dr. Suparno Chakrabarti and colleagues in the United Kingdom.

Stem cell recipients who underwent nonmyeloablative conditioning with Campath-1H suffered from a high CMV infection rate, although this was mitigated by their low...

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Source: Blood Weekly (2002-08-15)

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