Cell Expansion

Chimeric gene amplifies number of progeny formed after stem cell stimulation

Published in Blood Weekly, August 29th, 2002

by Sonia Nichols, senior medical writer - A new amplifier gene has enabled scientists to increase the number of genetically modified cells that develop after stem cells are implanted into a nonhuman primate model.

Human hematopoietic stem cell transfection can be problematic when retroviral vectors are the gene transfer vehicle, according to Y. Hanazono and colleagues, Jichi Medical School, Tochigi, Japan.

"Strategies that would allow in vivo expansion of gene-modified hematopoietic cells could circumvent the problem," Hanazono and colleagues argued.

The multicenter team, which included investigators from both Japan and the U.S.,...

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Source: Blood Weekly (2002-08-29)

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