Atherosclerosis

Intrinsic coagulation pathway helps mediate plaque-induced thrombosis

Published in Blood Weekly, September 12th, 2002

by Michael Greer, senior medical writer - Researchers in the United States and Japan have presented evidence challenging widely held assumptions about the hemostatic effects of arterial plaque.

"Thrombosis is the major mechanism underlying acute complications of atherosclerosis," explained Dr. Natalya M. Ananyeva and colleagues at the American Red Cross' Holland Laboratory in Rockville, Maryland and Nara Medical University in Nara, Japan.

Plaque-induced thrombosis may be mediated by the intrinsic coagulation pathway, in contrast to the conventional wisdom that this morbidity develops through the extrinsic pathway, Ananyeva and coauthors found.

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Source: Blood Weekly (2002-09-12)

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