Gene Delivery

Semidisabled herpes simplex virus vector effectively targets PBMCs

Published in Blood Weekly, January 9th, 2003

"Peripheral blood mononuclear cells (PBMCs) represent a significant target for gene delivery both for therapeutic and experimental purposes. Thus far however, it has proved difficult to develop vectors capable of high efficient gene delivery to unstimulated PBMCs," noted researchers in England.

K. Papageorgiou and colleagues, University College of London, Institute of Child Health, said they "tested a range of different vectors derived from herpes simplex virus (HSV) which differ in their degree of disablement in terms of their gene delivery efficiency to unstimulated human PBMCs and ability to deliver a reporter gene."

They found that "[n]one of...

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Source: Blood Weekly (2003-01-09)

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