Published in Blood Weekly, January 23rd, 2003
"The use of retroviral gene transfer into hematopoietic stem cells (HSCs) for human gene therapy has been hampered by the absence of retroviral vectors that can generate long-lasting, lineage-specific gene expression," Peter J. Gough remarked in the January 2003 issue of Blood.
Gough and colleagues at the Seattle, Washington, university used fragments from the human CD68 gene to make retroviruses macrophage-specific. CD68 is a macrophage-restricted...
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