Transduction

Modified retrovirus able to guide macrophages after gene transfer

Published in Blood Weekly, January 23rd, 2003

by Sonia Nichols, senior medical writer - Scientists at the University of Washington may have solved the dilemma of poor gene expression arising from retrovirus-based gene delivery to some cells.

"The use of retroviral gene transfer into hematopoietic stem cells (HSCs) for human gene therapy has been hampered by the absence of retroviral vectors that can generate long-lasting, lineage-specific gene expression," Peter J. Gough remarked in the January 2003 issue of Blood.

Gough and colleagues at the Seattle, Washington, university used fragments from the human CD68 gene to make retroviruses macrophage-specific. CD68 is a macrophage-restricted...

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Source: Blood Weekly (2003-01-23)

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