Transfusion Medicine

Alloimmunization to RhD antigen studied in non-myeloablative transplants

Published in Blood Weekly, January 23rd, 2003

According to a study from England, "Following exposure to RhD antigen, anti-D develops in up to 20% of RhD-negative patients on chemotherapy, but seldom in the recipients of hemapoietic cell (HC) or solid-organ transplants. Data on anti-D formation come from HC transplants using myeloablative conditioning; no data are available for the non-myeloablative HC transplants.

"The two types of transplant have a distinct isohemagglutinin disappearance rate and different kinetics of post-transplant red-cell engraftment," wrote A. Mijovic and colleagues at the University of London's King's College Hospital.

These hematologists analyzed anti-D formation in 16...

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Source: Blood Weekly (2003-01-23)

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