Blood Testing

In-cell PCR method may improve maternal blood-based fetal genotyping

Published in Blood Weekly, January 30th, 2003

According to recent research from Denmark, "during recent years, much attention has been paid to the possibility of using fetal cells circulating in the pregnant woman's blood for prenatal diagnosis of genetic or chromosomal abnormalities."

T.V. Hviid and colleagues, Copenhagen University Hospital, wrote: "Although successes have been achieved in enrichment procedures for fetal cells from maternal blood samples, the use of such an approach for genotyping by molecular biology techniques in a more routine setting has been hampered by the large contamination of maternal nucleated blood cells in the cell isolates. Therefore, a new method based on in-cell PCR is described,...

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Source: Blood Weekly (2003-01-30)

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