Acute Myeloid Leukemia

Selective apoptosis induced in primary human leukemic stem cells

Published in Blood Weekly, February 13th, 2003

"Acute myelogenous leukemia (AML) is typically a disease of stem/progenitor cell origin," according to a study from the University of Kentucky. "Interestingly, the leukemic stem cell (LSC) shares many characteristics with normal hematopoietic stem cells (HSCs) including the ability to self-renew and a predominantly G₀ cell-cycle status."

"Thus, although conventional chemotherapy regimens often ablate actively cycling leukemic blast cells, the primitive LSC population is likely to be drug-resistant," explained M. L. Guzman and coworkers. "Moreover, given the quiescent nature of LSCs, current drugs may not effectively distinguish between malignant stem cells...

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Source: Blood Weekly (2003-02-13)

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