Kidney Transplantation

Heightened CD69 expression marks CMV viremia, but not rejection

Published in Blood Weekly, February 27th, 2003

"It has been reported that acute allograft rejection is associated with heightened expression of the peripheral blood lymphocyte (PBL) early activation marker CD69 and that this may serve as a potential biomarker of rejection," according to a recent study from Canada.

M. Karpinski and colleagues at the University of Manitoba "sought to determine whether PBL CD69 expression correlates with both acute clinical and subclinical renal allograft rejection as well as clinically inapparent cytomegalovirus (CMV) infection."

"Flow cytometric determination of PBL CD69 expression was performed at the time of clinical and protocol biopsies (n = 131) in 45 renal...

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Source: Blood Weekly (2003-02-27)

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