Leukemia

A causal role of CD38 identified in leukocyte differentiation

Published in Blood Weekly, February 27th, 2003

According to a study from the United States, "granulocytic differentiation of human HL-60 cells can be induced by retinoic acid and is accompanied by a massive expression of CD38, a multifunctional enzyme responsible for metabolizing cyclic ADP-ribose (cADPR), a Ca2+ messenger."

"Immunofluorescence staining showed that CD38 was expressed not only on the surface of intact HL-60 cells but also intracellularly, which was revealed after permeabilization with Triton. Concomitant with CD38 expression was the accumulation of cADPR, and both time courses preceded the onset of differentiation, suggesting a causal role for CD38," stated C.B. Munshi and coauthors, University of...

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Source: Blood Weekly (2003-02-27)

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