Hematology

Factor VIIIa subunit interaction altered after factor Xa cleavage

Published in Blood Weekly, March 13th, 2003

Factor VIIIa interactions with its subunits are altered after factor Xa cleavage of the A1 subunit.

According to a study from the United States, "factor VIIIa consists of subunits designated A1, A2, and A3-C1-C2."

"The limited cofactor activity observed with the isolated A2 subunit is markedly enhanced by the Al subunit," explained K. Nogami and coauthors, University of Rochester. "A truncated Al (A1(336)) was previously shown to possess similar affinity for A2 and retain similar to 60% of its A2 stimulatory activity."

Nogami and coworkers found "a second site in A1 at Lys(36) that is cleaved by factor Xa. A1 truncated at both...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Blood Weekly

Source: Blood Weekly (2003-03-13)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry