Published in Blood Weekly, March 13th, 2003
According to a study from the United States, "factor VIIIa consists of subunits designated A1, A2, and A3-C1-C2."
"The limited cofactor activity observed with the isolated A2 subunit is markedly enhanced by the Al subunit," explained K. Nogami and coauthors, University of Rochester. "A truncated Al (A1(336)) was previously shown to possess similar affinity for A2 and retain similar to 60% of its A2 stimulatory activity."
Nogami and coworkers found "a second site in A1 at Lys(36) that is cleaved by factor Xa. A1 truncated at both...
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