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Blood Clots

Low dose warfarin prevents recurrence of blood clots; study stopped early

Published in Blood Weekly, March 27th, 2003

A study of long-term, low-dose warfarin to prevent the recurrence of the blood clotting disorders deep vein thrombosis (DVT) and pulmonary embolism resulted in such a high degree of benefit to the patients - without significant adverse effects - that the National Heart, Lung, and Blood Institute (NHLBI) of the U.S. National Institutes of Health has stopped the study early.

The multicenter Prevention of Recurrent Venous Thromboembolism (PREVENT) trial found a 64% reduction in episodes of DVT and pulmonary embolism in study participants taking low-dose warfarin compared to those taking a placebo. Furthermore, there was no evidence of significant risks such as major...

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