HIV/AIDS Gene Therapy
Cyclophilin A binding region blocks lentiviral vector simian cell transduction
Published in Blood Weekly, April 3rd, 2003
"HIV-1 replication in simian cells is restricted at an early postentry step because of the presence of an inhibitory cellular factor," explained researchers in the United States. "This block reduces the usefulness of HIV-1-based lentiviral vectors in primate animal models."
N. A. Kootstra and colleagues at the Salk Institute for Biological Studies found that "substitution of the cyclophilin A (CyPA) binding region in the capsid of an HIV-1-based lentiviral vector (LV) with that of the macrophage tropic HIV-1 Ba-L resulted in...
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Source: Blood Weekly (2003-04-03)
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