Ischemic Stroke
Location of TNFalpha and its receptors by cell type was determined in brain
Published in Blood Weekly, April 10th, 2003
A study from Poland "evaluated immunocytochemistry cellular localization and time-dependent expression of tumor necrosis factor (TNF-alpha) and its receptors p55 (TNF-R1) and p75 (TNF-R2) in human ischemic brains. We observed them in microglia, neurons, astrocytes, macrophages, and blood vessels. Since TNF-alpha expression was very intense and prolonged in microglia, it probably constitutes the main cellular source of the cytokine following cerebral ischemia in humans."
"Constitutive expression of TNF-alpha receptors was observed in neurons and blood vessels while in other...
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Source: Blood Weekly (2003-04-10)
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