HIV/AIDS Pathogenesis
DC-SIGN has cell-type dependent role in viral entry
Published in Blood Weekly, April 24th, 2003
"DC-SIGN (CD209) is a C-type lectin expressed by several groups of dendritic cells (DC), including those derived from blood monocytes and DC found beneath genital epithelium," researchers in New York explained. "DC-SIGN binds the envelope glycoprotein of HIV-1 and facilitates transmission of infectious virus to permissive CD4+ T cells."
To elucidate the role of this molecule in HIV infection, C. Trumpheller and coauthors at Rockefeller University "compared the capacity of DC-SIGN in different cell types to bind, retain and transmit infectious HIV-1 to T cells."
"The...
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Source: Blood Weekly (2003-04-24)
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