Published in Blood Weekly, April 24th, 2003
Stem cell factor (SCF) "is a potent pro-proliferative cytokine crucial for hematopoiesis, which binds to c-kit and activates its tyrosine kinase activity," according to researchers in Italy. "Inactivating mutations of either SCF or c-kit have been described in mice and lead to increased sensitivity to treatment with ionizing radiation."
"Imatinib is a tyrosine kinase inhibitor with high affinity for c-Abl, PDGFR and c-kit," explained H. Ruchatz and colleagues at the National Cancer Institute, who "investigated the effect of concomitant administration of imatinib...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Blood Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.