B Cell Regulation

Pten in B cells controls homeostasis and IgG class switch recombination

Published in Blood Weekly, May 8th, 2003

The tumor suppressor Pten has roles in B cells ranging from B cell development and homeostasis to control of autoantibody production.

"Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox)/(flox)mice). The bPten(flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies," scientists writing in the Journal of Experimental Medicine report.

"Among B2 cells in bPten(flox/flox) spleens, numbers of marginal zone B (MZB) cells were significantly increased while those of follicular B (FOB) cells were correspondingly...

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Source: Blood Weekly (2003-05-08)

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