Published in Blood Weekly, May 8th, 2003
"Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox)/(flox)mice). The bPten(flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies," scientists writing in the Journal of Experimental Medicine report.
"Among B2 cells in bPten(flox/flox) spleens, numbers of marginal zone B (MZB) cells were significantly increased while those of follicular B (FOB) cells were correspondingly...
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