Sickle Cell Anemia

ICA-17043 prevents erythrocyte dehydration in mice

Published in Blood Weekly, May 8th, 2003

A novel Gardos channel inhibitor prevents erythrocyte dehydration in mice with sickle cell anemia.

According to recent research from the United States, "a prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation."

"Loss of potassium (K+), chloride (Cl-), and water from RBCs is thought to contribute to the production of these dehydrated cells," explained J.W. Stocker and colleagues at Icagen Inc.. "One main route of K+ loss in the RBC is the Gardos channel, a calcium (Ca2+)-activated K+ channel."

"Clotrimazole (CLT), an inhibitor of the Gardos channel, has been shown to reduce RBC...

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Source: Blood Weekly (2003-05-08)

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