Stem Cell Research

Oncoprotein MLL-ENL disrupts early lineage determination

Published in Blood Weekly, May 8th, 2003

A protein associated with mixed-lineage leukemia (MLL) disrupts early lineage determination in hematopoietic stem cells.

MLL fusion proteins "are associated with a unique class of leukemia that is characterized by the simultaneous expression of lymphoid-specific as well as myeloid-specific genes," according to investigators in Germany who developed "the first experimental model of MLL."

In this model, "murine bone marrow cells were retrovirally transduced to express the MLL-eleven nineteen leukemia (MLL-ENL) fusion protein," B.B. Zeisig and colleagues at the University of Erlangen-Nurnberg wrote in the journal Oncogene.

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Source: Blood Weekly (2003-05-08)

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