Umbilical Cord Blood

Impaired MAP kinase signaling may explain T-cell phenotype

Published in Blood Weekly, May 8th, 2003

Impaired MAP kinase signaling may explain functional deficiencies in umbilical cord blood T cells.

"The biochemical basis for the reduced lymphokine production by neonatal T cells compared with adult T cells remains poorly defined," investigators in Australia noted, although "previous studies have raised the possibility that neonatal T cells could be deficient in their ability to transmit signals via protein kinase (PK) C."

In a recent study, C.S.T. Hii and coauthors at the Women's and Children's Hospital in Adelaide found that "PKC-dependent activation of the mitogen-activated protein (MAP) kinases, c-Jun N-terminal protein kinase and the...

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Source: Blood Weekly (2003-05-08)

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