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Genomics

Potential role identified for Wnt signaling in hematopoietic recovery

Published in Blood Weekly, May 15th, 2003

Researchers in Canada have identified a potential role for Wnt signaling in hematopoietic recovery.

According to a study from Ontario, "Human hematopoietic stem cells are defined by their ability to repopulate multiple hematopoietic lineages in the bone marrow of transplanted recipients and therefore are functionally distinct from hematopoietic progenitors detected in vitro.

"Although factors capable of regulating progenitors are well established, in vivo regulators of hematopoietic repopulating function are unknown," wrote B. Murdoch and colleagues, John P. Robarts Research Institute.

"By using a member of the vertebrate Mint...

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