Hematopoiesis

Src pathway inactivation in Kit impairs blood cell growth & proliferation

Published in Blood Weekly, May 22nd, 2003

In activation of the Src pathway in Kit results in impaired blood cell growth and proliferation, report Indiana University researchers.

According to their study in the Journal of Biological Chemistry, "Kit receptor tyrosine kinase and erythropoietin receptor (Epo-R) cooperate in regulating blood cell development. Mice that lack the expression of Kit or Epo-R die in utero of severe anemia. Stimulation of Kit by its ligand, stem cell factor, activates several distinct early signaling pathways, including phospholipase Cgamma, phosphatidylinositol 3-kinase, Src kinase, Grb2, and Grb7. The role of these pathways in Kit-induced growth, proliferation, or cooperation...

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Source: Blood Weekly (2003-05-22)

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