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Stem Cell Transplantation

Reduced-intensity SCT allows low toxicity, rapid engraftment from siblings

Published in Blood Weekly, May 22nd, 2003

A report from Mexico indicates reduced intensity stem cell transplantation in children enables rapid engraftment from their siblings.

According to D. Gomez-Almaguer and colleagues, "A group of 21 consecutive patients aged 4-20 (median 13) years was prospectively allografted using a reduced intensity preparative regimen. The group included both malignant (acute lymphoblastic leukemia, acute myelogenous leukemia, and chronic myelogenous leukemia) and nonmalignant (aplastic anemia, Diamond-Blackfan anemia, thalassemia major, and adrenoleukodystrophy) conditions. Follow-up times ranged between 16 and 1038 days."

The researchers reported graft-versus-host...

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