Leukemia
Monoclonal gene markings need to be differentiated with leukemic gene therapy
Published in Blood Weekly, May 29th, 2003
According to a study from the United States, "a clinical trial of retroviral-mediated transfer of the adenosine deaminase (ADA) gene into umbilical cord blood CD34(+) cells was started in 1993. ADA-containing peripheral blood mononuclear cells (PBMCs) have persisted in patients from this trial, with T lymphocytes showing the highest prevalence of gene marking(1,2). To gain a greater understanding of the nature and number of the transduced cells that were engrafted, we used linear amplification-mediated PCR (LAM-PCR) to identify clonal vector proviral integrants(3,4)."
"In...
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Source: Blood Weekly (2003-05-29)
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