Stem Cell Transplantation

T-cell depletion with Campath-1H 'in the bag' has multiple benefits

Published in Blood Weekly, May 29th, 2003

T-cell depletion of peripheral blood stem cell graft recipients with Campath-1H 'in the bag' appears to help reduce graft-versus-host disease (GVHD), speed immune constitution, and improve survival, study results indicate.

Hematologists at the Birmingham Heartlands Hospital, U.K., "studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n=14) or 10 mg (n=10) Campath-1H in vitro." This group was compared "with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients."

Among the researchers' findings:

Neutrophil engraftment was similar between groups

...

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Source: Blood Weekly (2003-05-29)

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