Allogeneic BMT
Pretreatment of donor with IL-18 attenuates acute GVHD, but preserves GVL effect
Published in Blood Weekly, May 29th, 2003
"Interleukin-18 (IL-18) is a unique cytokine that modulates both T(H)1/IT(H)2 responses, but its ability to modulate diseases through induction of T(H)2 cytokines is unclear.
"It has been shown to play an important role in allogeneic bone marrow transplantation (BMT).
"Because immune responses of allogeneic BM donors may affect acute graft-versus-host disease (GVHD), we investigated the effect of pretreating BM transplant donors with IL-18 on the severity of acute GVHD using...
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Source: Blood Weekly (2003-05-29)
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