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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 5th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Chronic Myelogenous Leukemia - Oncogene-expressing stem cells downregulate tumor suppressor BRCA1

Stem Cell Transplantation - Nonmyeloablative conditioning enables marrow-induced tolerance

Acute Lymphoblastic Leukemia - Intensified GVHD prophylaxis enables haploidentical stem cell transplants

Hematology - Postnatal bone marrow stromal cells could stimulate therapeutic angiogenesis

Stem Cell Research -  Pumilio proteins expressed by murine hematopoietic cells

Stem Cell Research - Adult bone marrow only reliable source of mesenchymal stem cells

Acute Lymphoblastic Leukemia - Gene dosage aids detection of 9p21 deletions in children

Aplastic Anemia - Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma

Asthma - Theophylline induces progenitor cell apoptosis

Bioengineering - AMEGA facilitates the selection of genetically modified cell populations

Bleeding Disorder - Acquired von Willebrand syndrome occurs in some geriatric patients

Blood Safety - FDA still lacks timetable for tissue bank oversight

Blood Substitute - Phase Ib/II clinical trial for Hemospan begins

Bone Marrow Transplant - Lymphoproliferative disorder can have EBV infection in both B and T cells

Cancer Immunotherapy - TNF-alpha production induced from human monocytes by beta-1,3-glucan oligomer

Fanconi Anemia - Novel conditioning regimen enables mismatched stem cell transplants

Finance - Hemodialysis concentrate maker reports revenues, updates trials

Finance - Vaccine producer provides updates on corporate programs

Gene Expression - Method achieves RNA interference in differentiated embryonic stem cells

Hematology - Bleeding disorder tied to defect in cellular transport mechanism

Hematology - Flt-3 ligand antagonizes thrombopoietin in myelosuppressed primates

Kawasaki Disease - Immunoglobulin failure and retreatment can occur in anemic pediatric patients

Leukemia - PTEN protein may be absent in B-CLL with a normal PTEN genotype

Liver Disease - Bone marrow stem cells may one day help treat damaged livers

Lymphoma - 11778 Mutation does not change cellular response to cytotoxic drugs

Mosquito-borne Diseases - The origin of blood meals can help epidemiological tracking, using PCR

Needle Safety - Breakthrough needle-destruction device receives FDA approval

Neurogenesis - Pluripotent neural progenitor cells are present in the adult human brain

Non-Hodgkin Lymphoma - CBV conditioning for stem cell transplantation safe and effective

Pancreatic Cancer - Scientists uncover role of Fanconi anemia genes

SARS - China broadens usage of i-STAT system

Stem Cell Policy - Researchers call for changes

Stem Cell Research - Alliance with NIA follows completion of analyses of precursor cells

Stem Cell Research - Bone marrow-derived hepatocytes arise from cell fusion

Stem Cell Research - Genetically modified stem cells prevent juvenile diabetes in mice

Stem Cell Research - Knowing pathways that regulate vascular stem cells opens up treatment choices

Stem Cell Research - Murine serpin 2A protein is intracellular and redox-sensitive

Stem Cell Research - Novel epithelial-mesenchymal stromal cells identified in fetal liver

Stem Cell Research - Patented stem cell expansion technology acquired

Stem Cell Research - Platelet-derived growth factor upregulates megakaryocytic transcription factors

Stem Cell Research - Selective amplifier genes containing c-Mpl augment hematopoietic cell expansion

Stem Cell Research - The tetrapeptide AcSDKP induces angiogenesis in vitro and in vivo

Stem Cell Transplantation - Allografts effective against chronic granulomatous disease

Stem Cell Transplantation - Cidofovir effective but toxic for adenovirus-infected patients

Stem Cell Transplantation - Cord blood grafts linked to heightened cytomegalovirus risk

Stem Cell Transplantation - Extracorporeal photopheresis moderately effective against GVHD

Stem Cell Transplantation - Feto-maternal microchimerism prevents T-cell reactions

Stem Cell Transplantation - GVHD effects similar in normal and reduced-intensity transplants

Stem Cell Transplantation - Metronidazole alters busulfan pharmacokinetics

Stem Cell Transplantation - Single leukapheresis should be used for pediatric solid tumor patients

Stem Cell Transplantation - Treatment effective for t(8;13)-related myeloproliferative disorder

Sudden Cardiac Death - Johns Hopkins receives $24 million from Donald W. Reynolds Foundation

Thalassemia - Study finds deferiprone provides significantly greater cardiac protection

Thrombocytopenia Purpura - Short-term, high-dose cyclosporin may be useful in pediatric refractory disease

Transfusion Medicine - Methods to reduce bacterial infections from blood transfusions considered

Transfusion Medicine - Quality of life reports linked to hemoglobin levels in MDS patients

Umbilical Cord Blood - Bacterial molecules activate cord blood-derived mast cells

Umbilical Cord Blood - Fibrinogen promotes megakaryocytopoiesis, but not thrombopoiesis

Umbilical Cord Blood - Novel purification method improves Langerhans cell yield

V.I. Technologies, Inc. - Blood supply company reports first quarter financial results

Vector Development - Endothelial progenitor-like cells are angiogenesis-selective gene vectors

West Nile Virus - CDC inks licensing agreement for test for WNV

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