Published in Blood Weekly, June 5th, 2003
So the researchers set about developing a way to obtain more efficient RNA interference in differentiated cells and came up with a technique that works "in totipotent and differentiated ES cells together with a wide range of other mammalian cell types that is both simple and efficient," said J.B. Grabarek and colleagues.
A linearized plasmid is used "that directs the expression...
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