Murine serpin 2A protein is intracellular and redox-sensitive

"Murine serpin 2A is expressed at high levels in hemopoietic progenitors and downregulated on differentiation," researchers in Australia explained. "When it is constitutively expressed in the multipotent hemopoietic cell line, FDCP-Mix, it causes a delay in differentiation and increased clonogenic potential."

"The serpin is also dramatically upregulated on T-cell activation," noted E.C. Morris and coauthors at Monash University. "It has an unusual reactive site Cys-Cys sequence, a unique C-terminal extension and lacks a typical cleavable N-terminal signal sequence. In spite of these...

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