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Umbilical Cord Blood

Fibrinogen promotes megakaryocytopoiesis, but not thrombopoiesis

Published in Blood Weekly, June 5th, 2003

Fibrinogen promotes megakaryocytopoiesis, but not thrombopoiesis in umbilical cord blood.

"Megakaryocyte differentiation is composed of three distinct stages: formation of erythromegakaryocytic progenitor cells, maturation of megakaryocytes and production of platelets," researchers in Japan explained.

T. Sato and coauthors at the Tokyo Medical and Dental University "developed a liquid culture system for megakaryocyte terminal differentiation from hematopoietic stem cells into proplatelets."

"In this system, CD34+ cells isolated from human cord blood, differentiated to CD41+ cells, were classified either as propidium iodide (PI)+...

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