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Aplastic Anemia

Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma

Published in Blood Weekly, June 5th, 2003

Antithymocyte globulin and cyclosporine therapy can lead to development of Merkel cell carcinoma.

According to published research from Japan, "We report a patient who developed Merkel cell carcinoma (MCC) after treatment with antithymocyte globulin and cyclosporine for aplastic anemia.

The clinical course was progressive and prognosis poor," wrote M. Takabayashi and colleagues.

The researchers concluded: "Although MCC is relatively rare in second cancers arising after immunosuppressive therapy, patients should be closely monitored for the development of this complication as well as other second malignancies."

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