Acute Myeloid Leukemia

Flow cytometric assay detects apoptosis proteins in residual tumor cells

Published in Blood Weekly, June 12th, 2003

A flow cytometric assay can measure apoptosis protein expression by residual leukemia cells.

"Minimal residual disease (MRD) cells are thought to be responsible for the persistence and relapse of acute myeloid leukemia (AML)," scientists in the Netherlands explained. "Flow cytometric MRD detection by the establishment of a leukemia-associated phenotype (LAP) at diagnosis can be used in 80% of AML patients, allowing detection and functional characterization of MRD in follow-up bone marrow."

"One of the mechanisms contributing to inefficient chemotherapy is apoptosis resistance," noted A. van Stijn and coauthors at the Vrije University of Amsterdam....

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Source: Blood Weekly (2003-06-12)

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