Stem Cell Research
5-Azacytidine can reactivate erythroid potential of myeloid-restricted cells
Published in Blood Weekly, June 19th, 2003
According to recent research from Italy, "32D cells grown for one year in interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) generated the 32D Ro cell line, which retained the parental mast cell phenotype but lost the ability to generate erythroid cells in response to erythropoietin (EPO)."
"In order to clarify the mechanisms underlying such restriction," M. Baiocchi and coauthors at the Istituto Superiore di Sanita in Rome "compared 32D and 32D Ro cells for their capacity to express erythroid-specific transcription factors (Gata1,...
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Source: Blood Weekly (2003-06-19)
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