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Biomaterials

Negative cilia concept enhances blood compatibility of PEO-SO3 polymers

Published in Blood Weekly, June 26th, 2003

Scientists at the Korea Institute of Science & Technology in Seoul have designed sulfonated PEO (PEO-SO3 ) "as a 'negative cilia model' to investigate a synergistic effect of PEO and negatively charged SO3 groups."

Writing in the journal Biomaterials, Y.H. Kim and colleagues said, "PEO-SO3 itself exhibited a heparin-like anticoagulant activity of 14% of free heparin. Polyurethane grafted with PEO-SO3 (PU-PEO-SO3 ) increased the albumin adsorption to a great extent but suppressed other proteins, while PU-PEO decreased the adsorption of all the proteins. The platelet adhesion was decreased on PU-PEO but...

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