Published in Blood Weekly, June 26th, 2003
"Despite improvements in treatment, the 5-year survival for metastatic colorectal cancer remains poor. Novel approaches such as gene immunotherapy are being investigated to improve treatment. Retroviral gene transfer methods have been shown to transduce primary human T lymphocytes effectively resulting in the expression of therapeutic genes," investigators in England report.
"However, a number of defects have been identified in T lymphocytes isolated from patients bearing tumor, which may have critical implications for the development of gene-targeted T cells as an...
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